Is finasteride a cytotoxic drug and can induce DNA base excision repair. The clinical use of finasteride in male and
is finasteride a cytotoxic drug female patients has been reported.[2]
Drug Interaction
Some interactions between finasteride and drugs are known as "inducible inhibition models". A list of active ingredients used in many male and female treatments has been compiled. The list shows which products contain the active ingredients that may interact with finasteride.[2]
Alcohol
Finasteride is known to have an alcohol inhibitory effect when used with alcohol. Therefore, long-term use of finasteride and its in the face of a prior history alcohol misuse or alcoholism finasteride london drugs should be discouraged.[Citation needed]
Hematologic Conditions
In animal studies, finasteride is known to enhance the effects of hematologic malignancies.[2,24] Therefore, if a patient was being treated for leukemia, he should be warned of the potential benefits and risks related to his cancer therapy while taking finasteride.
Fibroids
When patients are being treated for fibroids, they should be advised to stop using finasteride if they continue experiencing an increase in the size of their fibroids, particularly within the first year of therapy. In addition, patients should be warned to discontinue their treatment in the event they experience a tumor recurrence or relapse.[2]
Hereditary Prostate Malignancies
Finasteride has been associated with a decrease in serum prostate-specific antigen, a predictor of the risk developing prostate cancer and of the extent disease. However, it should be noted that was not found to significantly modify or predict progression to prostate cancer among patients who were treated for prostate cancer.[2,24]
Prostate Cancer
Finasteride is not generally considered a treatment for treatment-resistant prostate cancer. However, some urologic oncologists report an increase in prostate cancer their practice following initiation of finasteride therapy.[2] is known to induce apoptosis, or programmed cell death, in cultured prostate cancer cells.[2,25] Finasteride can induce cellular changes in prostate cells that promote tumor growth and progression.[2] Finasteride has also been shown to interfere with the normal cell growth cycle in prostate cancer cells.[2] Further research is necessary to determine the extent which finasteride will affect the growth cycle of prostate cancer.[2]
Although there have been no well-controlled long-term studies for patients receiving finasteride prophylaxis and treatment of prostate cancer (or other diseases), the results of such studies have shown an adverse effect on the prostate, with a lower urinary excretion of prostatic fluid, an increase in fluid on palpation and blood measurements a higher risk for side effects. However, such changes were seen at doses used in the treatment of prostate cancer.[2]
It is important to note that finasteride is not associated with a higher risk for death from prostate cancer and all causes in postmenopausal men. Therefore, the recommendation for men
discount pharmacy warehouse online to continue taking finasteride (at doses appropriate to address prostate specific antigen and other risk factors) for their health will be met. The decision to discontinue treatment with finasteride in those men cancer does.
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Drugs that interact with finasteride on the surface of human epidermal keratinocytes," they report.
The study indicates that it is unlikely this drug interaction was a cause for concern but did highlight important issues to consider when testing for such an interaction.
They propose that the risk of such
Buy generic propecia online an interaction is reduced with thorough monitoring of drug levels before starting a treatment regimen, especially if the subject is young or if the subject has body weight loss and increased water, among other factors. By: Robert Salonga
Published: 02/18/2012 08:42 AM EDT on SPACE.com
NASA's robotic Dawn probe, which just arrived at the asteroid Vesta on Saturday (Feb. 12), likely has seen a very rare instance of meteorite hitting one the space agency's observatories, a NASA probe says.
The meteorite, researchers believe, could contain precious metals — platinum, palladium and gold from a space mission that's ongoing drugs similar to finasteride at Vesta. The impact occurred in Vesta region, a region that includes large number of meteorites, said John Grunsfeld, associate administrator of the National Aeronautics and Space Administration.
The impact likely occurred on Feb. 7, 2012, around 6 a.m. local time (1300 GMT), according to an analysis of data from NASA's Near-Earth Object Observations program.
Dawn captured the asteroid on Feb. 8 as it zipped by, a distance of about 3,700 miles, or 6,800 kilometers.
"The mission success is the result of combination observatory, spacecraft and orbiter we're looking forward to the exciting science expected be conducted by Dawn soon," Grunsfeld said.
Viewing Vesta's atmosphere from above is a great way to study how it responds changes in its proximity to the sun, he added.
In February, the craft will
Finast 5mg $141.86 - $2.36 Per pill make its closest approach to the alien world, which lies about 4.5 billion miles from Earth, before heading back with a probe that will study the surface.
Editor's note: This article originally stated that a meteorite fell onto one of NASA's observatories, but it was actually
Acetazolamide price uk the Vesta spacecraft that came under attack by asteroids.
Follow SPACE.com on Twitter @Spacedotcom. We're also Facebook finasteride drugbank & Google+.
Copyright 2012 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
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